Škrott Zdeněk Ph.D.

Journals

LACEY, M., L. BÉRESOVÁ, A. SROVNALOVÁ, P. POLISHCHUK, M. SALA, Z. ŠKROTT, M. HAJDÚCH, P. DŽUBÁK, J. BÁRTEK, A. ŠIŠKOVÁ, M. LOFFELMANN, R. NENCKA, M. MISTRÍK
Autophagy revealed as a targetable vulnerability in senescent cells by cell painting phenotypic profiling: a mechanistic study of MCOPPB and related compounds. Geroscience. 2026, ISSN: 2509-2723, PMID: 42062708,  PDF.
HUANG, J., J. CAMPIAN, T. DEWEES, Z. ŠKROTT, M. MISTRÍK, T. JOHANNS, G. ANSSTAS, O. BUTT, E. LEUTHARDT, G. DUNN, G. ZIPFEL, J. OSBUN, C. ABRAHAM, S. BADIYAN, K. SCHWETYE, J. CAIRNCROSS, J. RUBIN, A. KIM, M. GHEDA
A Phase 1/2 Study of Disulfiram and Copper With Concurrent Radiation Therapy and Temozolomide for Patients With Newly Diagnosed Glioblastoma. International Journal of Radiation Oncology, Biology, Physics. 2024, 120(3), 738-749, ISSN: 0360-3016, PMID: 38768767,
LOFFELMANN, M., Z. ŠKROTT, D. MAJERA, P. STARHA, V. KRYŠTOF, M. MISTRÍK
Identification of novel dithiocarbamate-copper complexes targeting p97/NPL4 pathway in cancer cells. European Journal of Medicinal Chemistry. 2023, 261, 115790, ISSN: 0223-5234 , PMID: 37690264,

Books & book chapters

ŠKROTT, Z.
Methods for detection and induction of proteotoxic stress response in mammalian cells , 1.vyd., Olomouc, Palacky University, 2021, 23, 169-176, Dedication: LO1304, ISBN: 978-80-244-6049-9,

Intellectual property

BIOAVAILABLE DITHIOCARBAMATE-METAL COMPLEX NANOPARTICLES, METHOD OF PREPARATION AND USE THEREOF "DISULFIRAM I" (Škrott)
  1. Patent: EP 3459526. Granted: 24.2.2021. Ownership: Palacky University, Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  2. Published Application PCT/EP2018/076098 under WO 2019/063601 (4.4.2019)
  3. Patent: AU 2018340510. Granted: 5.8.2021. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  4. Patent: CA 3,076,855. Granted: 26.4.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  5. Patent: KR 10-2456683. Granted: 14.10.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  6. Patent: JP 2020-537873. Granted: 29.9.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.
  7. Patent: MX 396,552. Granted: 17.10.2022. Ownership: Palacký University Olomouc. Inventors: Škrott Zdeněk, Mistrík Martin, Hajdúch Marián, Bártek Jiří, Džubák Petr, Zbořil Radek.

Status: Available

CELL CULTURE DEVICE AND METHOD FOR THERMAL MICRO-IRRADIATION OF CELLS "PLASMONS" (Mistrík)
  1. Published Application: EP 20198904.3 under EP 20198904 (7.4.2022). Ownership: Palacky University, Olomouc. Inventors: Mistrík Martin, Škrott Zdeněk, Bártek Jiří, Panáček Aleš, Kvítek Libor, Hochvaldová Lucie.

Status: Terminated

 

LIQUID CHROMATOGRAPHY COLUMN (Mistrík)

Utility Model: CZ 35118. Granted: 1.6.2021. Ownership: Palacky University, Olomouc. Inventors: Mistrík Martin, Škrott Zdeněk, Oždian Tomáš.

Status: Available

Master mentorship

Machačová Zuzana M.Sc.

The role of the p97 / NPL4 protein complex in repairing damaged DNA

Status: Graduated from 2019 to 2021.
Loffelmann Martin

Identification of new inhibitors of NPL4 protein and insight into the mechanism of their action

Status: Graduated from 2020 to 2022.
Svobodová Natálie

Targeting heat shock proteins in cancer

Status: Ongoing from 2023.

Bachelor mentorship

Soos Andrej

Crosstalk between the ubiquitin proteasome system and genome integrity

Status: Graduated from 2016 to 2017.
Kempná Magdalena

Targeting NPL4 protein in cancer

Status: Graduated from 2019 to 2020.

Open positions

Project: Cellular stress in health and disease
Supervisors: Mistrík Martin Ph.D., Moudrý Pavel Ph.D., Škrott Zdeněk Ph.D.
Available: 3
Intended for: Doctoral training